自从Renoux G和Renoux M发现左旋咪唑(LMS图1)能增强小鼠接种布氏菌苗的预防效果以来,人们对LMS的免疫调节、促进作用进行过大量的、广泛的研究。经过对各种报告和实验资料的分析才发现,LMS有着广泛的、但又相当局限的作用范围,它仅作用于成熟的和未成熟的T淋巴细胞和吞噬细胞。研究早期,人们把LMS的作用,较多地看成免疫刺激或免疫促进作用,进一步的研究表明,在治疗浓度(10~(-5)～10~(-6)M)下,LMS的作用大多数发生在 Since Renoux G and Renoux M discovered that levamisole (LMS Figure 1) enhances the prophylactic effect of vaccination in mice, the immunomodulatory effects of LMS have been extensively and extensively studied. After a variety of reports and experimental data analysis found that LMS has a wide range, but a very limited role, it only applies to mature and immature T lymphocytes and phagocytes. In the early part of the study, the role of LMS was seen more as an immunostimulatory or immunosuppressive effect. Further studies showed that the effect of LMS at the therapeutic concentration (10 -5 to 10 -6 M) Most happen