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近年来注意到,硷性液体疗法所致的高渗透压血症为引起新生儿颅内出血的一个主要原因。本文著者等用幼小和新生家兔仔以7%NaHCO_3做实验,结果硬膜下出血发生率都很高。随着血渗透压的上升,出血亦增加,并且经毛细血管镜观察证明高渗透压血症可使脑毛细血管通透性增加。根据这些材料确定高渗透压血症是引起新生儿脑损伤,尤其是颅内出血的一个主要原因。临床上应用硷性液体疗法时,必须在有充分认识的基础上,在适当的条件下应用。自1961年Usher提倡对特发性呼吸窘迫综合征(IRDS)应用NaHCO_3疗法以来,至今仍普遍应用,本病预后也有改善。但从1964年Euchison主张按硷缺失行快速矫正法后,于1974年Simmons就指出用NaHCO_3所致
In recent years, it has been noted that hypervolemic hyperlipidemia caused by alkaline liquid therapy is one of the main causes of neonatal intracranial hemorrhage. The author and other young and newborn rabbit Aberdeen to 7% NaHCO_3 experiment, the results of subdural hemorrhage rates are high. With the increase of blood osmolality, hemorrhage also increased, and capillary capillary observation showed that hypertonic hypercapnia can increase brain capillary permeability. Hypertrophic hyperosmolarity based on these materials is one of the major causes of neonatal brain injury, especially intracranial hemorrhage. Clinical use of alkaline liquid therapy, we must have a full understanding of the basis, under the appropriate conditions. Since 1961, Usher advocated the application of NaHCO 3 therapy in patients with idiopathic respiratory distress syndrome (IRDS), it is still widely used and the prognosis of this disease is also improved. However, after Euchison advocated the rapid correction of the alkaline deficit line in 1964, Simmons pointed out in 1974 that using NaHCO 3