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洋葱醇提物可治疗动物及人的支气管哮喘,发现这与洋葱中的硫代亚磺酸酯类(TS)成分有关。TS对组胺释放、白三烯和血栓素合成及致敏原和PAF引起的支气管梗阻和过敏反应有抑制作用。本文比较了TS和Ccpacncs(CS)对花生四烯酸代谢的抑制作用。从洋葱中分离或合成的九种TS和四种CS(0.25～100μmol/L)显著抑制绵羊精囊微体环氧酶(CA)和猪白细胞5-脂氧酶(LO)的活性,并呈剂量依赖关系,对LO的抑制作用比对CA的更显著,CS是迄今从洋葱中分离出的LO和CA最有效抑制
Onion alcohol extracts treat bronchial asthma in animals and humans and found that this is related to the thiosulfinate (TS) component in onions. TS has inhibitory effects on histamine release, leukotriene and thromboxane synthesis, and bronchial obstruction and hypersensitivity induced by allergens and PAF. This article compares the inhibition of arachidonic acid metabolism by TS and Ccpacncs (CS). Nine TSs and four CSs (0.25 to 100 μmol/L) isolated or synthesized from onion significantly inhibited seminal vesicle microsomal cyclooxygenase (CA) and porcine leukocyte 5-lipoxygenase (LO) activity in sheep and were dosed Dependency, the inhibitory effect on LO is more significant than that of CA. CS is the most effective inhibitor of LO and CA isolated from onion so far.