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HBV前S_2基因(Pre—S_2)蛋白在HBV感染中作为病毒复制的一项指标具有一定的临床意义。特别是在急性乙型肝炎时血清中的Pre—S_2蛋白与HBsAg有密切联系,但在慢性乙型肝炎时血清中Pre—S_2:蛋白滴度是否与HBsAg的滴度有差别,国内报道较少。本文对82例急性和慢性乙型肝炎HBsAg HBeAg,抗-HBe和Pre-S_2蛋白测定,结果表明,在急性乙型肝炎血清中Pre-S_2蛋白滴度与HBsAg滴度呈平行关系,但在慢性乙型肝炎中,急性发作期与恢复期有滴度差别。现将实验结果报道如下:
Pre-S_2 protein (Pre-S_2) protein in HBV infection as an indicator of viral replication has some clinical significance. Especially in the case of acute hepatitis B, the Pre-S 2 protein in serum is closely related to HBsAg. However, there is a difference between the serum titer of Pre-S 2 and the titer of HBsAg in chronic hepatitis B, . In this paper, 82 cases of acute and chronic hepatitis B HBsAg HBeAg, anti-HBe and Pre-S 2 protein determination, the results show that in patients with acute hepatitis B Pre-S 2 protein titer and HBsAg titer was parallel, but in chronic Hepatitis B, acute exacerbation and recovery of the titer difference. The experimental results are reported as follows: