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作者报告自1972年至1980年对73例急性淋巴细胞细胞白血病(ALL)的患儿采用~(198)Au 加MTX 鞘内注射预防中枢神经系统的脑膜侵犯。73例中,男39例、女34例;年龄为4个月到17岁。经过化疗在血液学检查完全缓解后,鞘内注入~(198)Au 和MTX。~(198)Au的用量视年龄而定。2岁以下1.5 mci,2～3岁2.5mci,4～10岁3 mci,10～14岁3.5 mci,14～16岁4 mci,16岁以上5 mci。方法是将放射性药物用同位素校准仪测量后用生理盐水稀释,容积为12～15 ml/
The authors report the intrathecal injection of ~ (198) Au plus MTX for the prevention of meningeal invasion of the central nervous system in 73 children with acute lymphoblastic leukemia (ALL) from 1972 to 1980. In 73 cases, 39 males and 34 females; aged 4 months to 17 years old. After chemotherapy hematologic examination was completely relieved, intrathecal injection of ~ (198) Au and MTX. ~ (198) The amount of Au depends on the age. 1.5 mci under 2 years old, 2.5 mci at 2 ~ 3 years, 3 mci at 4 ~ 10 years, 3.5 mci at 10 ~ 14 years, 4 mci at 14 ~ 16 years, and 5 mci at 16 years old. The method is to use radioisotope isotope calibrator after measurement with physiological saline diluted volume of 12 ~ 15 ml /