目的探讨水化疗法预防造影剂肾病的疗效。方法选择2008年3月至2012年3月在我院接受冠状动脉造影术及PCI术的80例住院患者。随机分为两组:水化治疗组为研究组,常规治疗为对照组。测定患者于术前、术后第2、3天清晨空腹抽查患者血清肌酐及监测患者尿量。术前详细记录患者姓名、性别、年龄及合并症,术后记录患者并发症及详细的造影剂用量并观察尿量。结果患者应用造影剂前后血肌酐变化水化治疗组造影剂应用后2 d血肌酐与应用前比较有增高趋势,常规治疗组应用造影剂后第2天血肌酐水平显著高于应用前,差异有统计学意义(P<0.05)。结论在围手术期积极采用静脉输液的方式水化治疗,是临床上预防CIN的一种有效方法,且方法简单,使用安全,疗效可靠,值得推广。 Objective To investigate the curative effect of hydration on preventing contrast agent nephropathy. Methods Eighty inpatients undergoing coronary angiography and PCI from March 2008 to March 2012 were enrolled in this study. Randomly divided into two groups: hydration treatment group for the study group, conventional treatment for the control group. Determination of patients in preoperative and postoperative 2,3 days fasting random serum creatinine patients and monitoring of urine output. Preoperative detailed records of patient name, gender, age and comorbidities, postoperative patient complications and detailed contrast agent dosage and observe urine output. Results Before and after administration of contrast medium, serum creatinine was changed. Serum creatinine increased 2 days after the application of contrast agent in the hydration therapy group. Serum creatinine was significantly higher on the second day after contrast agent administration in the conventional treatment group than before Statistical significance (P <0.05). Conclusions In the perioperative period, the active use of intravenous infusion of hydration therapy is an effective method to prevent CIN clinically. The method is simple, safe, reliable and worthy of promotion.