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目的：评价恶性肿瘤患者的免疫球蛋白反应类型。方法：将血清免疫球蛋白（Ｉｇ）剖解为游离和复合两部分进行研究。以食管癌、喉癌、胃癌、乳腺癌、子宫癌、鼻咽癌、卵巢癌和非霍奇金淋巴瘤（ＮＨＬ）与健康者分别为实验组和对照组。结果：患者游离Ｉｇ的变化与总Ｉｇ一致，而复合Ｉｇ则与之不同，对其的检测更有利于对患者免疫状况的评价。从而说明，既往有关血清Ｉｇ含量的测定，主要反映游离Ｉｇ部分的免疫反应状况。结论：免疫反应产物的剖解分析可以更进一步认识免疫反应本质。在对肿瘤患者Ｉｇ比例的研究中，发现肿瘤患者的复合ＩｇＧ普遍严重下降。从而认为特异性ＩｇＧ水平的明显下降是患者免疫功能降低的重要原因，并提出深入研究其机理，将可能为探索肿瘤发病机理和治疗找到一条新路
Objective: To evaluate the type of immunoglobulin response in patients with malignant tumors. METHODS: Serum immunoglobulin (Ig) was dissected into two parts, free and complex, for study. Esophageal cancer, laryngeal cancer, gastric cancer, breast cancer, uterine cancer, nasopharyngeal cancer, ovarian cancer, and non-Hodgkin’s lymphoma (NHL) were compared with healthy subjects in the experimental group and the control group. Results: The change of free Ig was consistent with the total Ig, but the composite Ig was different. The detection of free Ig was more conducive to the evaluation of the patient’s immune status. This shows that the previous determination of serum Ig content mainly reflected the immune response status of the free Ig part. Conclusion: The anatomical analysis of the immune response products can further understand the nature of the immune response. In the study of the proportion of Ig in cancer patients, it was found that the combined IgG of cancer patients generally declined. Therefore, it is believed that the marked decline in the specific IgG level is an important cause of the decrease in the immune function of patients, and it is proposed to further study its mechanism and it may be possible to find a new path for exploring the pathogenesis and treatment of tumors.