目的探讨幽门螺杆菌（Ｈｐ）感染与胃癌部位及组织类型的关系．方法胃镜及病理证实的胃癌７３例，男女之比为２０４∶１，平均年龄为５６０岁．其他肿瘤患者７３例（食管癌２２例；结直肠癌１９例；肺癌２１例；乳腺癌１１例），男女之比为１７０∶１，平均年龄为５５６岁，进行１∶１病例一对照研究，采用间接ＥＬＩＳＡ法检测血清抗ＨｐＩｇＧ抗体水平，将Ｈｐ抗体分为３个等级．结果胃癌组Ｈｐ感染率为５８９％，平均抗体水平为２２９±０８５（ｘ±ｓ），显著高于对照组的感染率４２５％（Ｐ＜００５）和平均抗体水平１８４±０６５（Ｐ＜００１）．Ｈｐ感染率在对照组的分布情况为食管癌４０９％，结直肠癌４７４％，肺癌３８１％，乳腺癌４５５％．胃癌组与对照组相比，机会比值呈线性趋势（Ｐ＝０００５４６０）．Ｈｐ阳性率在非贲门部胃腺癌为７４４％，明显高于贲门部腺癌４０７％（Ｐ＜００５）．结论Ｈｐ感染与胃癌有关，特别与非贲门部腺癌关系密切．胃癌的危险性随抗ＨｐＩｇＧ抗体滴度升高而升高． Objective To investigate the relationship between Helicobacter pylori (Hp) infection and the site and tissue type of gastric cancer. Methods Seventy-three cases of gastric cancer were confirmed by gastroscopy and pathology. The ratio of male to female was 204∶1. The average age was 560 years old. 73 cases of other cancer patients (22 cases of esophageal cancer; 19 cases of colorectal cancer; 21 cases of lung cancer; 11 cases of breast cancer), male to female ratio of 1 to 70:1, average age of 55 to 6 years, 1:1 case In a controlled study, serum anti-HpIgG antibodies were detected by indirect ELISA and Hp antibodies were divided into three grades. Results The Hp infection rate in the gastric cancer group was 58.9%, and the average antibody level was 229±085(x±s), which was significantly higher than the control group’s infection rate of 42.5% (P<005) and average. The antibody level was 184±065 (P<001). The distribution of Hp infection rate in the control group was 40.9% for esophageal cancer, 47.4% for colorectal cancer, 38.1% for lung cancer, and 45.5% for breast cancer. Compared with the control group, the odds ratio of the gastric cancer group showed a linear trend (P=0005460). The positive rate of Hp in non-cardiac gastric adenocarcinoma was 74.4%, which was significantly higher than that of adenocarcinoma of the cardia (40.7%) (P < 0.05). Conclusion Hp infection is associated with gastric cancer, especially with non-cardiac adenocarcinoma. The risk of gastric cancer increases with increasing anti-HpIgG antibody titers.