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目的:评估常规血清肿瘤标记检测卵巢成熟囊性畸胎瘤的意义,指导临床正确选用肿瘤标记物。方法:回顾性分析125例卵巢成熟囊性畸胎瘤患者的临床资料。结果:患者平均年龄为34.1岁;肿瘤平均直径(49.6±19.8)mm,中位数为46 mm;4种血清肿瘤标记物水平CA199为(74.1±135.8)U/L,CA125为(17.2±15.3)U/ml,AFP为(2.3±1.6)μg/L,CEA为(1.4±0.9)μg/L,升高率分别为35.2%(44/125)、4.9%(6/122)、0%、0%,肿瘤双侧率为40.0%(50/125)。CEA、AFP在检测卵巢成熟囊性畸胎瘤中无意义,CA125与CA199有一定意义;血清CA199水平高的患者瘤体较大,且较低水平者其肿瘤为双侧的可能性显著升高(72.7%vs 22.2%,P<0.05)。双侧的似然比CA199为1.8,CA125为3.2。结论:CEA、AFP对于检测卵巢成熟囊性畸胎瘤无意义,CA199有一定意义,可指导手术医生对于双侧性肿瘤的探查以及治疗。
Objective: To evaluate the significance of routine serum tumor markers in the detection of ovarian mature cystic teratoma and to guide the clinical selection of tumor markers. Methods: A retrospective analysis of 125 cases of ovarian mature cystic teratoma in patients with clinical data. Results: The average age of the patients was 34.1 years old. The mean tumor diameter was 49.6 ± 19.8 mm and the median was 46 mm. The serum tumor markers CA499 (74.1 ± 135.8) U / L, CA125 (17.2 ± 15.3) ), URE / ml, AFP was (2.3 ± 1.6) μg / L, CEA was (1.4 ± 0.9) μg / L and the rates of increase were 35.2% (44/125), 4.9% (6/122) , 0%, bilateral rate of the tumor was 40.0% (50/125). CEA, AFP in the detection of ovarian mature cystic teratoma is of no significance, CA125 and CA199 have a certain significance; high serum CA199 patients with larger tumors, and the lower the possibility of bilateral tumor was significantly higher (72.7% vs 22.2%, P <0.05). The likelihood ratios for both sides were 1.8 for CA199 and 3.2 for CA125. Conclusion: CEA and AFP are of no significance for the detection of ovarian mature cystic teratoma. CA199 is of some significance, which can guide surgeons in the exploration and treatment of bilateral tumors.