论文部分内容阅读
本文报告了16例临床患者,一次静脉注射400微克心房利钠多肽(心钠素)的治疗效果。 6例患者为原发性高血压病,静脉注射心钠素以后,30分钟内,其收缩压、舒张压和平均动脉压分别降低了24±5,10±7和17±5 mmHg。每分和每搏心输出量、左室射血分数较用药前显著增加。尿量、尿钠和尿肌酐排泄量较用药前增加2～4倍。用药后,血浆抗利尿激素的浓度降低,但血浆肾素、血管紧张素浓度无明显变化。
This article reports the treatment of 16 patients with a single intravenous injection of 400 micrograms of atrial natriuretic peptide (atrial natriuretic peptide). 6 patients with essential hypertension, intravenous injection of atrial natriuretic peptide within 30 minutes, systolic blood pressure, diastolic blood pressure and mean arterial pressure were reduced by 24 ± 5,10 ± 7 and 17 ± 5 mmHg. Per minute and stroke cardiac output, left ventricular ejection fraction was significantly increased compared with before treatment. Urine volume, urinary sodium and urinary creatinine excretion increased 2 to 4 times before treatment. After treatment, plasma antidiuretic hormone concentration decreased, but plasma renin, angiotensin concentration no significant change.