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目的探讨四联疗法根除幽门螺杆菌(Hp)对慢性胃疾病的治疗效果。方法选取河南科技学院医院消化内科收治的Hp感染慢性胃疾病患者79例,随机分为对照组(36例)和观察组(43例),给予对照组三联疗法根除Hp治疗,给予观察组四联疗法根除Hp治疗;比较两组Hp根除率、临床疗效、治疗后血液学指标包括血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平及不良反应发生情况。采用SPSS 19.0统计软件进行统计分析,计量资料用均数±标准差(xˉ±s)表示,采用t检验,计数资料用率(%)表示,采用χ2检验,P<0.05表示差异有统计学意义。结果观察组和对照组Hp根除率分别为90.70%和72.22%,差异有统计学意义(P<0.05),治疗后观察组血清TNF-α(15.59±4.49)ng/L、IL-6(11.70±4.44)ng/L明显低于对照组(P<0.05);两组均无血、尿、粪常规及肝、肾功能无异常改变,两组不良反应率比较差异无统计学意义(P>0.05)。结论与三联疗法治疗Hp感染慢性胃疾病相比,四联疗法Hp根除率、对慢性胃疾病治疗的临床总有效率明显更高,并可明显降低患者血清TNF-α、IL-6水平,且不会增加不良反应率,安全可靠。
Objective To investigate the therapeutic effect of quadruple therapy on chronic gastric diseases by eradicating Helicobacter pylori (Hp). Methods Seventy-nine patients with Hp-infected chronic gastric diseases admitted to Department of Gastroenterology, Henan University of Science and Technology Hospital were randomly divided into control group (36 cases) and observation group (43 cases). Patients in control group were treated with triple therapy to eradicate Hp, Hp eradication rate was compared between two groups. The curative effect of Hp eradication rate and the hematological indexes including serum levels of TNF-α, IL-6, CRP, Level and adverse reactions occurred. Statistical analysis was performed using SPSS 19.0 statistical software. The measurement data were expressed as mean ± standard deviation (xˉ ± s), t test was used and the count data (%) was used. Chi-square test was used. P <0.05 was considered statistically significant . Results The Hp eradication rates in the observation group and the control group were 90.70% and 72.22%, respectively, with significant difference (P <0.05). After treatment, the serum levels of TNF-α and IL-6 ± 4.44) ng / L was significantly lower than that of the control group (P <0.05). No abnormalities in blood, urine, fecal routine, liver and kidney function were found in both groups. There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusions The Hp eradication rate of quadruple therapy is significantly higher than that of triple therapy in the treatment of chronic gastric diseases with Hp infection. The total effective rate of Hp eradication therapy for chronic gastric diseases is significantly lower, and serum TNF-α and IL-6 levels are significantly decreased Will not increase the adverse reaction rate, safe and reliable.