【摘 要】
：
CURLY LEAF (CLF) encodes the methyltransferase subunit of the Polycomb Repressor Complex 2 (PRC2),which regulates the expression of target genes through H3K27 t
【机 构】
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Instituto de Agrobiotecnologia del Litoral(CONICET-UNL), Cátedra de Biologia Celulary Molecular, Fac
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CURLY LEAF (CLF) encodes the methyltransferase subunit of the Polycomb Repressor Complex 2 (PRC2),which regulates the expression of target genes through H3K27 trimethylation.We isolated a new CLF mutant allele (clf-78) using a genetic screen designed to identify microRNA (miRNA) deficient mutants.CLF mutant plants showed impaired miRNA activity caused by increased ubiquitination and enhanced degradation of ARGONAUTE 1 (AGO1) in specific tissues.Such CLF-mediated AGO1 regulation was evident when plants were exposed to UV radiation,which caused increased susceptibility of clf mutants to some UV-induced responses.Furthermore,we showed that CLF directly regulates FBW2,which in tu triggers AGO1 degradation in the clf mutants.Interestingly,AGO1 bound to a target appeared particularly prone to degradation in the mutant plants,a process that was exacerbated when the complex bound a non-cleavable target.Thus,prolonged AGO1-target interaction seems to favor AGO1.degradation,suggesting that non-cleavable miRNA targets may overcome translation inhibition by modulating AGO1 stability in plants.
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