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目的:观察消异方对子宫内膜异位症大鼠异位内膜P75NTR的影响,探讨消异方治疗子宫内膜异位症的机制。方法:采用自体手术移植法建立大鼠子宫内膜异位症模型,随机分为模型组、米非司酮组、散结镇痛胶囊组、消异方低、中、高剂量组。造模成功各组给药4W,免疫组化方法检测大鼠异位子宫内膜组织P75NTR的表达情况。结果:模型组异位内膜中P75的表达水平明显高于米菲司酮组、散结镇痛胶囊组和中药消异方各剂量组(P<0.05)。结论:消异方能降低大鼠子宫内膜P75NTR的含量,以达到治疗子宫内膜异位症所引起的慢性盆腔疼痛的作用。
Objective: To observe the effect of Xiaoyifang on ectopic endometrial P75NTR in rats with endometriosis and to explore the mechanism of Xiaofang Recipe in treating endometriosis. Methods: A rat model of endometriosis was established by autologous transplantation. The rats were randomly divided into model group, mifepristone group, Sanjiezhitong Capsule group, Xiaoyu Fang low, medium and high dose groups. The successful model was given 4W in each group. The expression of P75NTR in ectopic endometrium was detected by immunohistochemistry. Results: The expression level of P75 in ectopic endometrium of model group was significantly higher than that of Mifepristone group, Sanjiezhitong capsule group and each dose group of Hesan Fang (P <0.05). Conclusion: Hsieh Fang can reduce the content of P75NTR in endometrium in rats, so as to achieve the effect of treating chronic pelvic pain caused by endometriosis.