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目的:通过调查,为抗菌药物合理应用提供依据。方法:收集2005—2007年抗菌药物使用和药敏数据,对使用类别及金额构成、DDDs排序和耐药性进行分析。结果:我院头孢菌素类、大环内酯类和青霉素类用量处于前3位;DDDs排序中阿奇霉素、阿莫西林、左氧氟沙星和头孢哌酮舒巴坦居前4位;铜绿假单胞菌对亚胺培南出现耐药,阿奇霉素、头孢吡肟与喹诺酮类耐药增加,头孢曲松耐药普遍。结论:阿奇霉素、头孢吡肟与喹诺酮类等用量大的品种耐药增加明显,表明用药量与耐药存在相关性。
Objective: Through investigation, provide basis for the rational application of antibacterial drugs. Methods: The data of antimicrobial use and drug susceptibility from 2005 to 2007 were collected. The categories of usage and the composition of the amounts, DDDs ranking and drug resistance were analyzed. Results: The top three cephalosporins, macrolides and penicillins were used in our hospital. Among the top four DDZs, azithromycin, amoxicillin, levofloxacin and cefoperazone sulbactam ranked the top 4, Pseudomonas aeruginosa Resistant to imipenem, azithromycin, cefepime and quinolone resistance increased, ceftriaxone resistance is widespread. Conclusion: Azithromycin, cefepime and quinolones and other large dosage varieties increased significantly, indicating that there is a correlation between dosage and drug resistance.