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观察抗肝癌中药消结灵对小鼠移植实体型肝癌和S180肉瘤的抑制作用,超微病理改变,免疫组化定位,研究消结灵的抗癌机理。结果:实验组的肿瘤重量明显减轻,抗肝癌抑制率为48%~70%,抗S180肉瘤抑制率为36%~51%。在超微病理上,消结灵破坏癌细胞的膜系统,使其裂解崩溃;诱导癌细胞内产生大量溶酶体,致使其溶解变性坏死;激活淋巴细胞增生,免疫组化染色T淋巴细胞活性增强;枯否氏细胞功能旺盛,分泌免疫调节因子破坏癌细胞
To observe the anti-hepatocarcinoma Chinese medicine Hedrine on mice transplanted solid type hepatocellular carcinoma and sarcoma S180 inhibition, ultrastructural changes, immunohistochemical localization of anti-cancer mechanism of the anti-Ling. Results: The tumor weight of the experimental group was significantly reduced, the anti-hepatocellular carcinoma inhibition rate was 48% -70%, anti-S180 sarcoma inhibition rate was 36% -51%. Histopathology, Histoplasma destruction of cancer cell membrane system, so that the breakdown of collapse; Induced cancer cells produce a large number of lysosomes, resulting in the dissolution of the degeneration and necrosis; activation of lymphocyte proliferation, immunohistochemical staining of T lymphocyte activity Enhanced; Kupffer cells function exuberant, secretion of immune regulatory factor destruction of cancer cells