排斥反应是造成器官移植失败的首要原因 ,故而如何克服同种异体器官移植排斥反应成为移植领域的研究热点。就目前而言 ,诱导受者产生供者特异性免疫耐受是最科学、最有效的方法。本文就近年来几种主要移植免疫耐受诱导方法及其机制与应用作一简要综述。其中包括利用MHC肽段封闭受体T细胞TCR、封闭T细胞活化所必需的协同刺激因子及诱导受者体内产生嵌合状态。 Rejection is the primary reason for the failure of organ transplantation. Therefore, how to overcome the rejection of allogeneic organ transplantation has become a research hotspot in the field of transplantation. For now, inducing recipients to produce donor-specific immune tolerance is the most scientific and effective method. In this paper, in recent years, several major approaches to induce immune tolerance and its mechanism and application of transplantation for a brief review. These include the use of MHC peptides to block the TCR of recipient T cells, blocking the co-stimulatory factors necessary for T cell activation and inducing chimerism in the recipient.