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长链非编码RNAs(lnc RNAs)是一类转录本长度超过200nt、非编码蛋白质的RNAs。lnc RNAs能控制调节细胞的增殖、分化、凋亡及干细胞多能性。研究表明,lnc RNAs参与机体多种生命活动的调节,早期胚胎发育及病理性妊娠结局也受到lnc RNAs的一过性或长时间的调控。lnc RNAs差异表达与复发性流产、子痫前期、早产及胎儿生长受限等病理性妊娠结局密切相关。
Long-chain non-coding RNAs (lnc RNAs) are a class of RNAs that transcripts are over 200 nt in length and are non-coding proteins. lnc RNAs control the regulation of cell proliferation, differentiation, apoptosis and stem cell pluripotency. Studies have shown that lnc RNAs are involved in the regulation of a variety of life activities of the body, and early embryonic development and pathological pregnancy outcomes are also regulated by transient or long-term lnc RNAs. The differential expression of lnc RNAs is closely related to pathological pregnancy outcomes such as recurrent spontaneous abortion, preeclampsia, premature birth and fetal growth restriction.