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目的:探讨血必静注射液治疗小儿胰腺炎(CP)的效果。方法:选取2011年1月到2013年12月期间我院收治的胰腺炎患儿70例随机分为实验组和对照组,两组例数分别为40例和30例。实验组在对照组的基础上给予血必静静脉滴注,对照组采用常规消炎治疗,7d为1疗程,两组均连续治疗两个疗程。比较两组患者治疗前后的血清炎症因子水平、心率、呼吸、体温(T)、白细胞(WBC)和血淀粉酶(BA)恢复正常时间。结果:两组患者血清炎症因子水平均下降,实验组血清CRP、IL-6、TNF-α以及IL-18等血清炎症因子水平均较对照组显著降低(t_(CRF)=6.78,t_(IL-6)=4.92,t_(TNF-α)=3.05,t_(IL-18)=6.62,P<0.05)。与对照组比较,实验组治疗后的心率和呼吸得到良好控制,体温、白细胞和血淀粉酶恢复正常所需的时间也缩短,总治疗有效率明显增加,差异就有统计学意义(P<0.05)。结论:血必静注射液治疗小儿胰腺炎可有效控制炎症、缩短患儿体质恢复时间并提高疗效,值得临床推广使用。
Objective: To investigate the effect of Xuebijing injection on pediatric pancreatitis (CP). Methods: Seventy patients with pancreatitis admitted to our hospital from January 2011 to December 2013 were randomly divided into experimental group and control group, with 40 cases in each group and 30 cases in the control group. The experimental group was given Xuebijing intravenous drip on the basis of the control group, while the control group was treated by conventional anti-inflammatory treatment, 7d for a course of treatment, two groups were treated for two courses. Serum levels of inflammatory cytokines, heart rate, respiration, body temperature (T), white blood cell (WBC) and blood amylase (BA) recovery time before and after treatment were compared between the two groups. Results: Serum levels of inflammatory cytokines decreased in both groups. Serum levels of CRP, IL-6, TNF-α and IL-18 in the experimental group were significantly lower than those in the control group (t CRF = 6.78, t IL -6) = 4.92, t_ (TNF-α) = 3.05, t_ (IL-18) = 6.62, P <0.05). Compared with the control group, the heart rate and respiration in the experimental group were well controlled, and the time required for body temperature, white blood cells and blood amylase to return to normal was also shortened, and the total effective rate was significantly increased (P <0.05 ). Conclusion: Xuebijing injection for the treatment of pancreatitis in children can effectively control the inflammation, shorten the recovery time of the children and improve the curative effect, which is worthy of clinical promotion.