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目的:研究桃红四物丸对兔自体厚中厚皮片移植术后3个不同时限皮片成活的影响。方法:将60只新西兰大白兔随机分为两组,均进行皮片移植手术造模,治疗组予桃红四物丸灌胃治疗,对照组予等容积蒸馏水灌胃。通过免疫组化染色的方法,观察两组术后5d、8d和14d皮片VEGF的表达情况,并进行比较。结果:治疗组在术后5d、8d和14d均有较高的VEGF积分光密度值,其在3个时限的值均高于对照组(P<0.05)。两组内3个时限比较,VEGF的积分光密度值在术后14d达最高值(P<0.05)。结论:桃红四物丸对兔自体厚中厚皮片移植术后皮片VEGF的表达有促进作用,且在术后14d的作用最明显。
Objective: To study the effect of Taohongsiwu pill on the survival of the dermis in three different time periods after the autogenous thick and thick skin graft. Methods: Sixty New Zealand white rabbits were randomly divided into two groups. All of them were treated by skin graft. The treatment group was treated with Taohongsiwu pill. The control group was given equal volume of distilled water. Immunohistochemical staining method was used to observe the expression of VEGF in 5 days, 8 days and 14 days after operation in both groups. Results: The VEGF integral optical density value of the treated group was higher on the 5th, 8th and 14th day after operation, and the value of VEGF in the 3 groups was higher than that of the control group (P <0.05). The integral optical density of VEGF reached the highest value on the 14th day after operation (P <0.05). Conclusion: Taohongsiwu pill can promote the expression of VEGF in the skin of rabbits after autogenous thick and thick skin graft, and it has the most obvious effect after 14 days.