,Mouse intestinal Lgr5+ stem cells are more sensitive to heavy ion irradiation than Bmi1+stem cells

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Before the human exploration of the Mars or other long-duration missions in outer space,the risks of cancer and other radiation injury induced by space radiations,containing high linear energy transfer (LET) particles such as heavy ions,must be accurately estimated and mitigated.On the other hand,accelerated carbon ions have been successfully used for clinical tumor treatment,and their damages to normal tissues are also of conce.Therefore,heavy ion particles are severely risky not only to manned space exploration but also to the patients experiencing particle radiotherapy [1,2].
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