Manganese nodules on the ocean bed become attractive mineral resources because of its huge commercial benefits. In the last decades, a set of hydraulic lifting system with pipeline has been developed to mining these particles. It is inevitable that the lifting pipe will oscillate due to the its of operation and the motion properties of the solid in the two-phase flow will be changed because of the oscillating of pipeline. In this paper, the pressure gradient along the lifting pipeline was investigated with a series of experiments. At the same time, a new pressure drop prediction method on the basis of Lagrange simulation technique was worked out by use of an axial momentum balance and this method provides a way to predict the pressure loss of solid-liquid mixture. The results show that compared with the fixed pipe transportation, the pressure gradient of the oscillating pipe is greater than that of the fixed pipe because of the collision and unsteady friction between particles and the pipe wall due to the oscillating motion of the pipe. Moreover, it is found that the prediction results are in good agreement with those of the experiments.