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目的:探讨在规范化治疗高血压的基础上,加用麝香通心滴丸对高血压患者心肌纤维化的影响。方法:60例高血压患者随机分为两组,对照组30例及麝香通心滴丸治疗组30例。对照组采用“氨氯地平加/或比索洛尔”等治疗,治疗组在对照组治疗的基础上加用麝香通心滴丸,每天3次,每次2粒,观察6个月。所有患者在治疗开始及治疗结束时,行动态血压检测及血清Ⅰ型前胶原、Ⅲ型前胶原、透明质酸和层黏蛋白浓度测定。结果:与对照组相比,麝香通心滴丸治疗组患者血清Ⅰ型前胶原、Ⅲ型前胶原、透明质酸和层黏蛋白浓度水平明显降低,差异具有统计学意义(P<0.05和P<0.01),治疗组的24 h舒张压、白天舒张压水平较对照组下降明显,差异有统计学意义(P<0.05)。结论:麝香通心滴丸可以改善高血压患者心肌纤维化程度。
Objective: To discuss the effect of applying musk Tongxin Dripping Pills on myocardial fibrosis in hypertensive patients on the basis of standardized treatment of hypertension. Methods: Sixty hypertensive patients were randomly divided into two groups: control group (30 cases) and Shexiang Tongxin Dripping Pills (30 cases). The control group used “amlodipine plus / or bisoprolol ” and other treatment, the treatment group in the control group based on the treatment with the addition of musk Tongxiang dripping pills, 3 times a day, each 2, observed for 6 months. All patients at the beginning of treatment and at the end of treatment, ambulatory blood pressure and serum procollagen type Ⅰ, procollagen type Ⅲ, hyaluronic acid and laminin concentrations were measured. Results: Compared with the control group, the concentration of serum type Ⅰ procollagen, type Ⅲ procollagen, hyaluronic acid and laminin in patients treated with Shexiang Tongxin Dripping Pills decreased significantly (P <0.05 and P <0.01). The diastolic blood pressure at 24 hours and the diastolic blood pressure at daytime in the treatment group decreased significantly compared with the control group (P <0.05). Conclusion: Musk Tongxin Dripping Pills can improve myocardial fibrosis in hypertensive patients.