论文部分内容阅读
目的研究分析慢性丙肝患者(CHC)血清中自身抗体检测具有的临床意义。方法选取我院2015年2月-2016年6月收治的180例CHC患者作为研究对象,分别使用酶联免疫吸附试验(ELISA)和免疫印迹法(LIA)检测其血清自身抗体:血清抗结核抗体(ANA)阳性率、抗平滑肌抗体(SMA)阳性率和抗肝肾微粒体抗体(LKM)和抗线粒体抗体(AMA)阳性率、类风湿因子(RF)阳性率,比较自身抗体阳性组及阴性组患者的临床基本特征。结果慢性丙肝患者的自身抗体至少有一种阳性的有60例,阳性率为33.33%。ANA的阳性率>RF阳性率>AMA的阳性率>LKM-1的阳性率,ELISA的自身抗体检查率显著低于LIA自身抗体检出率,自身抗体阳性组患者的肝脏功能比较弱,丙型肝炎病毒发展较快。结论 CHC患者自身抗体检测对肝病治疗有积极意义,患者自身抗体是肝损伤的重要影响因素。
Objective To study the clinical significance of detecting autoantibodies in serum of patients with chronic hepatitis C (CHC). Methods A total of 180 CHC patients admitted from February 2015 to June 2016 in our hospital were enrolled in this study. Serum autoantibodies were detected by enzyme-linked immunosorbent assay (ELISA) and immunoblotting (LIA) (ANA) positive rate, anti-smooth muscle antibody (SMA) positive rate and anti-liver and kidney microsomal antibody (LKM) and anti-mitochondrial antibody (AMA) positive rate, rheumatoid factor (RF) positive rate, compared with autoantibody positive group and negative Group of patients with the basic clinical features. Results There were at least 60 positive autoantibodies in patients with chronic hepatitis C, the positive rate was 33.33%. ANA positive rate> RF positive rate> AMA positive rate> LKM-1 positive rate, ELISA autoantibody examination rate was significantly lower than LIA autoantibody detection rate, autoantibody positive group of patients with liver function is weak, type C Hepatitis virus develops rapidly. Conclusion CHC patients with autoantibodies detection of liver disease has a positive treatment, patients with autoantibodies is an important factor in liver injury.