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目的 探讨维生素D3鼻腔给药与变应性鼻炎患者血清免疫球蛋白(Ig)G4和IgE的相关性,研究维生素D3对变应性鼻炎免疫机制的影响.方法 选取皮肤点刺试验(SPT)阳性的变应性鼻炎患者30例为观察组,SPT阴性的单纯鼻中隔偏曲患者30例为对照组,经鼻腔滴入注射用维生素D3 30万U,每周1次共4次.治疗后7d,用散射放免法测定血清IgE、IgG4浓度.比较给药前后血清浓度变化.结果 观察组给药前血清IgE和IgG4浓度分别为(280.91±43.47)和(0.57±0.12)g/L,给药后分别为(204.64±46.32)和(0.88 ±0.12) g/L,给药前后比较差异均有统计学意义(P＜0.05);对照组给药前血清IgE和IgG4浓度分别为(45.47±6.01)和(0.42±0.07) g/L,给药后分别为(43.40±5.74)和(0.50±0.07) g/L,给药前后比较差异均无统计学意义(P＞0.05).结论 维生素D3对变应性鼻炎患者血清IgE和IgG4有不同程度的影响,维生素D3鼻腔给药可能成为变应性鼻炎预防和治疗的一种方法.“,”Objective To discuss the correlation between nasal administration of vitamin D3 and immunoglobulin (Ig) G4 and IgE in patients with allergic rhinitis (AR),and study the effect of vitamin D3 on the immune mechanism of AR.Methods Thirty patients with AR whose skin prick test (SPT) were positive were selected as observation group,and 30 patients with simple nasal septum deviation whose SPT were negative were selected as control group.All the patients were treated with vitamin D3 300 000 U nasal administration,once a week and 4 times in total.Seven days after treatment,the serum concentrations of IgE and IgG4 were measured by light-scattering and radio-immunoassay method.The changes were compared between before and after treatment.Results The serum concentrations of IgE and IgG4 in observation group before treatment were (280.91 ± 43.47) and (0.57 ± 0.12) g/L,and after treatment were (204.64 ± 46.32) and (0.88 ± 0.12) g/L,and there were statistical differences (P ＜ 0.05).The serum concentrations of IgE and IgG4 in control group before treatment were (45.47 ± 6.01) and (0.42 ± 0.07) g/L,and after treatment were (43.40 ± 5.74) and (0.50 ± 0.07) g/L,and there were statistical differences (P ＜ 0.05).Conclusions Vitamin D3 could affect the concentration of IgE and IgG4 in patients with AR.Vitamin D3 may become a prevention and treatment method for the AR.