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目的通过对肝癌患者血清中甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原125(CAl25)、糖类抗原199(CAl99)的检测分析,探索其与肝癌临床诊断与治疗中的相互关系,为肝癌的早期诊疗提供价值。方法选取2012—2014年新密市郑州新华医院、河南省省直第二医院肝癌确诊病人131例,同时选取健康体检者168例作为对照;采外周血3ml,分离血清,化学发光方法检测AFP、CEA、CAl25、CAl99的水平。结果肝癌血清中AFP、CEA、CA125、CA199的水平较健康对照组升高(P<0.05),而且肝细胞癌病人组血清中AFP水平升高明显,差异有显著性(P<0.01),而肝内胆管细胞癌病人组血清中的CEA、CAl25、CAl99水平升高明显,差异有显著性(P<0.01)。结论肝癌患者血清中AFP、CEA、CA125、CA199的水平均高于健康对照(P<0.05);AFP诊断肝细胞癌价值最高,CEA、CAl25、CAl99诊断肝内胆管细胞癌的价值最高;联合检测多项肿瘤标志物,则可以提高肝脏肿瘤的早期发现率。
Objective To explore the relationship between AFP, carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CAl25) and carbohydrate antigen 199 (CAl99) in hepatocellular carcinoma Interrelationship, for the early diagnosis and treatment of liver cancer provide value. Methods 131 cases of hepatocellular carcinoma diagnosed in Zhengzhou Xinhua Hospital of Xinmi City from 2012 to 2014 and 131 cases of liver cancer diagnosed by Henan Provincial Second Straight Hospital were enrolled. A total of 168 healthy subjects were selected as controls. Blood samples were collected from peripheral blood and serum samples were collected for chemiluminescence detection of AFP, CEA, CAl25, CAl99 levels. Results The levels of AFP, CEA, CA125 and CA199 in serum of hepatocellular carcinoma patients were significantly higher than those in healthy controls (P <0.05), and the serum levels of AFP in patients with hepatocellular carcinoma were significantly increased (P <0.01) Serum levels of CEA, CAl25 and CAl99 in patients with intrahepatic cholangiocarcinoma increased significantly (P <0.01). Conclusion The serum levels of AFP, CEA, CA125 and CA199 in patients with hepatocellular carcinoma were significantly higher than those in healthy controls (P <0.05). The highest value of AFP in the diagnosis of hepatocellular carcinoma was found. The diagnostic value of CEA, CA125 and CA199 was the highest in patients with intrahepatic cholangiocarcinoma. A number of tumor markers, you can improve the early detection of liver tumors.