通过对克雷伯氏菌β－内酰胺酶的测定，细菌转化及质粒接合转移等实验，发现大多数菌株的β－内酰胺酶是由质粒所编码的，少部分菌株的产生可能与细菌染色体ＤＮＡ编码有关。耐药质粒可通过接合转移方式转移至其他细菌，这在多重耐药克雷伯氏菌暴发流行中具有重要意义。 Through the determination of Klebsiella b-lactamase, bacterial transformation and plasmid conjugation transfer experiments found that most strains of β-lactamase is encoded by the plasmid, a small number of strains may be produced with the bacterial chromosome DNA coding. Resistant plasmids can be transferred to other bacteria by conjugative transfer, which is of great importance in the multi-drug resistant Klebsiella outbreak.