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半个世纪前,人们已经开始认识到肝硬化患者合并有血流动力学异常,主要包括心率、心输出量及血流量增加,外周血管阻力降低,心肌舒张收缩能力下降的高动力循环状态,可由血容量分布异常、神经体液调节紊乱、血管活性物质水平异常等引起。大量临床及实验研究证明,肝硬化患者可表现心肌收缩力减低及心肌对刺激反应减弱,尤其是在应激状态下更为明显,严重时可导致心力衰竭,该现象称为肝硬化心肌病[1],最初主要研究酒精性肝病,认为心脏输出量增加、在生理及药理应激状态下心脏收缩力
Half a century ago, people have begun to recognize that patients with cirrhosis with hemodynamic abnormalities, including heart rate, cardiac output and blood flow increased, decreased peripheral vascular resistance, decreased cardiac diastolic capacity hyperdynamic state, by Abnormal blood volume distribution, neurohumoral regulation disorders, abnormal levels of vasoactive substances caused. A large number of clinical and experimental studies have shown that patients with liver cirrhosis can reduce myocardial contractility and myocardial response to the stimulus weakened, especially in the stress state is more obvious, can lead to severe heart failure, the phenomenon known as cirrhosis of the liver [ 1], the initial study of alcoholic liver disease, that increased cardiac output, physiological and pharmacological stress in cardiac contractility