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目的:观察尼莫地平对烧伤脓毒症患者的临床效果。方法:选择2010年4月~2013年12月在我科住院治疗的84例烧伤脓毒症患者,随机分成两组,对照组接受常规治疗,治疗组在常规治疗的基础上再服用尼莫地平治疗。结果:一星期后,两组患者治疗后体温、心率、白细胞以及中性粒细胞比值下降的差值分别相比,差异有统计学意义(P<0.05);两组患者血清TNF-α、IL-6、IL-8下降的幅度分别相比均有统计学意义(p<0.05)。结论:尼莫地平显著降低炎性因子的表达,从而保护多器官功能,值得临床推广。
Objective: To observe the clinical effect of nimodipine on burn sepsis patients. Methods: Eighty-four burn sepsis patients admitted to our department from April 2010 to December 2013 were randomly divided into two groups. The control group received routine treatment. The treatment group received nimodipine treatment. Results: After one week, the differences of body temperature, heart rate, leucocyte and neutrophil ratio between the two groups after treatment were statistically significant (P <0.05). The levels of serum TNF-α, IL -6, IL-8 decreased compared to the magnitude of each statistically significant (p <0.05). Conclusion: Nimodipine significantly reduces the expression of inflammatory cytokines, thus protecting multiple organ functions and deserves clinical promotion.