【摘 要】
：
目的:探讨血清中甲胎蛋白(AFP)、异常凝血酶原Ⅱ(PIVKA-Ⅱ)、α-L-岩藻糖苷酶(AFU)联合检测对原发性肝癌(HCC)的诊断价值.方法:选择2018年1月 2019年7月住院的172例肝病患者为研究对象,其中HCC患者62例(HCC组)、肝硬化患者54例(肝硬化组)、慢性乙型肝炎患者56例(慢性乙型肝炎组).采用化学发光法检测AFP、PIVKA-Ⅱ,酶动力学法检测AFU,比较各组水平差异;采用秩和检验和受试者工作特性曲线(ROC)分析三者在HCC诊断中的价值.结果:HCC组的AFP、PIVKA-
【机 构】
：
淮安市第四人民医院检验科 江苏淮安,223002
论文部分内容阅读
目的:探讨血清中甲胎蛋白(AFP)、异常凝血酶原Ⅱ(PIVKA-Ⅱ)、α-L-岩藻糖苷酶(AFU)联合检测对原发性肝癌(HCC)的诊断价值.方法:选择2018年1月 2019年7月住院的172例肝病患者为研究对象,其中HCC患者62例(HCC组)、肝硬化患者54例(肝硬化组)、慢性乙型肝炎患者56例(慢性乙型肝炎组).采用化学发光法检测AFP、PIVKA-Ⅱ,酶动力学法检测AFU,比较各组水平差异;采用秩和检验和受试者工作特性曲线(ROC)分析三者在HCC诊断中的价值.结果:HCC组的AFP、PIVKA-Ⅱ和AFU水平均显著高于肝硬化组和慢性乙型肝炎组(P＜0.05);ROC曲线分析显示:AFP、PIVKA-Ⅱ和AFU用于诊断HCC的ROC曲线下面积分别为0.801、0.886和0.653.单项检测中,AFP的敏感度最高,为79.96％;PIVKA-Ⅱ的特异度与准确度均最高,分别为89.13％与83.77％.联合检测中,AFP+ PIVKA-Ⅱ组合的准确度最高,为85.82％,AFP+ PIVKA-Ⅱ+AFU的特异度最高,为98.80％;并联实验中AFP/PIVKA-Ⅱ/AFU组合的敏感度最高,为88.71％.结论:AFP、PIVKA-Ⅱ、AFU联合检测可以提高对HCC的诊断效能,弥补了单项检测的不足.
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