糖尿病、高血压、高脂血症等病理状态下,由于细胞正常的氧化还原稳态失衡,活性氧族(reactive oxygen species,ROS)过度产生而聚积,引起氧化应激。研究表明,氧化应激能引起内皮祖细胞(endothelial progenitor cells,EPCs)的数量减少,影响EPCs的动员、迁移、增殖及分化功能。EPCs能参与血管内皮的新生,对糖尿病血管病变有保护作用。故从某种意义上讲,外周循环中EPCs的数量和功能决定损伤 Diabetes mellitus, hypertension, hyperlipidemia and other pathological conditions, due to the normal cellular redox homeostasis, reactive oxygen species (ROS) over-accumulation and cause oxidative stress. Studies have shown that oxidative stress can reduce the number of endothelial progenitor cells (EPCs) and affect the mobilization, migration, proliferation and differentiation of EPCs. EPCs can participate in the newborn of vascular endothelium, have a protective effect on diabetic vascular lesions. So in a sense, the number and function of EPCs in the peripheral circulation determine the damage