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目的:通过测定血浆凝血酶原时间(PT),血清肝纤维化指标,分析肝硬化患者病程与PT、血清肝纤维化指标之间的关联。方法:对肝硬化患者的血清肝纤维化指标以及PT进行测定,再按照Child-pugh法把肝功能划分成A、B、C级。结果:肝硬化患者的血清肝纤维化指标会随着肝硬化患者病情的逐渐恶化而增高,PT会逐渐延长。肝硬化患者的血浆凝血酶原时间(PT)和层黏蛋白(LN)、IV型骨胶原(IV-C)、血清透明质酸(HA)和II型原胶原(HPCII)呈正相关。结论:肝硬化患者的肝纤维化与PT之间有着密切的关联。对肝硬化患者进行PT测定,能够准确有效的估测患者的肝硬化程度。
OBJECTIVE: To determine the correlation between the duration of prothrombocytopenia and PT and serum markers of liver fibrosis by measuring plasma prothrombin time (PT) and serum liver fibrosis markers. Methods: The indexes of liver fibrosis and PT in cirrhotic patients were determined, and then the liver function was divided into A, B and C according to Child-pugh method. Results: The index of serum fibrosis in patients with cirrhosis will increase with the gradual deterioration of patients with cirrhosis, PT will be gradually extended. Plasma prothrombin time (PT) was positively correlated with laminin (LN), type IV collagen (IV-C), serum hyaluronic acid (HA) and type II procollagen (HPCII) in patients with cirrhosis. Conclusion: There is a close relationship between liver fibrosis and PT in cirrhotic patients. PT measurement of patients with cirrhosis, can accurately and effectively estimate the degree of cirrhosis in patients.