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自Resenberg首次报道顺式二氯二氨合铂(Ⅱ)(简称顺氯铂)具有广谱高效的抗肿瘤活性之后,金属配合物作为新型的抗肿瘤药物引起普遍的重视,顺氯铂已广泛应用于治疗癌症的临床药物。为阐明其机理,对Pt(Ⅱ)的抗肿瘤配合物与核苷及其碱基的作用已进行了很多研究。结果表明,Pt(Ⅱ)抗肿瘤活性配合物必须是电中性分子,具有一对顺位易解离的
Since Resenberg was the first to report the broad spectrum of potent antitumor activity of cis-dichloro-platinum (II) (cis-cisplatin), metal complexes have gained widespread acceptance as novel antineoplastic agents, cisplatin Applied to the treatment of cancer clinical drugs. To elucidate its mechanism, much work has been done on the antitumor complexes of Pt (II) with nucleosides and their bases. The results show that the antitumor activity of Pt (Ⅱ) complexes must be neutral molecules with a pair of cis-position dissociation