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尾加压素II(UII)是最近几年才发现的一种血管活性肽,是目前所发现的最强的缩血管物质,1998年首次克隆成功人类UII。UII是一种生长抑素样环肽,结构呈高度保守性。人类UII的产生主要在脊髓和延髓的运动神经元,人心肌细胞、冠状动脉粥样硬化斑块、脂质沉积的平滑肌细胞和巨噬细胞中富含UII。UII受体GPR14主要在人心脏、动脉组织和胰腺中表达。在心力衰竭时UII有不同的变化,作用机制与改变血流动力学、心功能及参与心血管重构有关。该文就UII与心力衰竭的关系作一综述。
Urotensin II (UII) is a vasoactive peptide discovered in recent years. It is the strongest vasoconstrictor substance discovered so far. For the first time in 1998, it successfully cloned human UII. UII is a somatostatin-like peptide with a highly conserved structure. Human UII is produced mainly in motor neurons of the spinal cord and medulla, human cardiomyocytes, coronary atherosclerotic plaques, lipid-deposited smooth muscle cells and macrophages. UII receptor GPR14 is mainly expressed in human heart, arterial tissue and pancreas. UII in heart failure have different changes, the mechanism of action and changes in hemodynamics, cardiac function and involvement in cardiovascular remodeling. This article reviews the relationship between UII and heart failure.