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目的探讨前列地尔联合甲钴胺治疗糖尿病足的临床效果。方法 80例糖尿病足患者,随机分为观察组和对照组,每组40例。两组患者均给予常规治疗,在此基础上观察组患者采用前列地尔联合甲钴胺静脉输液治疗,对照组只采取甲钴胺静脉输液治疗。观察比较两组患者的临床效果。结果对照组的总有效率75.00%低于观察组的97.50%(χ~2=8.54,P<0.05)。观察组治疗前足背动脉血流速度为(0.45±0.08)m/s·mm~2,治疗后为(0.75±0.16)m/s·mm~2;对照组治疗前为(0.44±0.07)m/s·mm~2,治疗后为(0.65±0.13)m/s·mm~2,两组治疗前的足背动脉血流速度比较差异无统计学意义(t=0.59,P=0.28>0.05);治疗后,两组的足背动脉血流速度较治疗前均有一定程度的好转,且观察组的好转情况明显优于对照组(P<0.01);观察组治疗前的腓浅神经感觉传导速度为(40.12±4.05)m/s,治疗后为(44.38±4.23)m/s;对照组治疗前为(39.98±4.12)m/s,治疗后为(42.21±3.84)m/s,两组治疗前的腓浅神经感觉传导速度比较差异无统计学意义(t=0.15,P=0.44>0.05);治疗后,两组的腓浅神经感觉传导速度较治疗前均有一定程度的好转,且观察组好转情况明显优于对照组(P<0.05)。结论前列地尔联合甲钴胺治疗糖尿病足可提高临床治疗效果,改善足背动脉血流速度以及腓浅神经感觉传导速度,促进糖尿病足的恢复,降低致残率及致死率,提高患者生活质量,值得临床推广应用。
Objective To investigate the clinical effect of prostaglandin combined with mecobalamin in the treatment of diabetic foot. Methods 80 patients with diabetic foot were randomly divided into observation group and control group, 40 cases in each group. Two groups of patients were given conventional treatment, on the basis of observation group patients with alprostadil combined mecobalamin intravenous infusion, the control group only treated with intravenous mecobalamin. Observe and compare the clinical effect of two groups of patients. Results The total effective rate of the control group was 75.00%, which was lower than 97.50% of the observation group (χ ~ 2 = 8.54, P <0.05). The blood flow velocity of the dorsalis pedis artery was (0.45 ± 0.08) m / s · mm ~ 2 before treatment in the observation group and (0.75 ± 0.16) m / s · mm ~ 2 after the treatment in the observation group (0.65 ± 0.13) m / s · mm ~ 2 after treatment, there was no significant difference in the velocity of blood flow between the two groups before treatment (t = 0.59, P = 0.28> 0.05 ); After treatment, the dorsalis pedis artery blood flow velocity in both groups improved to a certain degree before treatment, and the improvement in the observation group was significantly better than that in the control group (P <0.01); The superficial peroneal nerve sensation in the observation group before treatment The mean velocity of conduction was (40.12 ± 4.05) m / s and (44.38 ± 4.23) m / s after treatment, while the control group was (39.98 ± 4.12) m / s before treatment and (42.21 ± 3.84) m / There was no significant difference in sensory and peroneal nerve conduction velocity between the two groups before treatment (t = 0.15, P = 0.44> 0.05). After treatment, the sensory velocity of peroneal nerve sensory nerve in both groups improved to a certain extent , And the observation group improved significantly better than the control group (P <0.05). Conclusion Alprostadil combined with mecobalamin may improve the clinical effect, improve the velocity of dorsalis pedis artery and the sensory velocity of peroneal nerve, promote the recovery of diabetic foot, reduce the morbidity and mortality, and improve the quality of life of patients ,Worthy of clinical application.