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肾间质纤维化是各种病因引起肾损伤,最终导致慢性肾脏病甚至肾衰竭的不可逆过程,其病理特征主要为肾间质内大量成纤维细胞增生,过量细胞外基质沉积以及肾组织结构能逐渐丧失.该病理阶段中,各种信号通路参与并相互影响,在肾纤维化的发生发展中起着重要的作用.因此,深入了解肾间质纤维化的发病机制,从而发掘特异性抗肾纤维化的治疗靶点是现阶段临床治疗的重要目标.文章对当前细胞信号通路调控肾纤维化的研究进展进行综述,以期为肾间质纤维化患者的治疗提供新方向.“,”Renal interstitial fibrosis (RIF) is an irreversible process of chronic kidney disease and renal failure characterized by numerous fibroblast proliferation,uncontrolled deposits of extracellular matrix,and progressive loss of renal function.In the pathological stage,a variety of signaling pathways are involved and interact with each other,which play an important role in the development of renal fibrosis.Therefore,it is significant to comprehend the pathogenesis of RIF and find specific targets for the treatment.This article reviews the current research progress in RIF mediated by signaling transduction pathways to provide a new direction for the treatment of RIF.