目的研究长春新碱(VCR)联合小剂量环磷酰胺(CTX)治疗系统性红斑狼疮(SLE)的安全性和对B细胞活化因子(BAFF)mRNA表达水平的影响。方法进行12周随机、对照研究,将纳入的SLE患者分为大剂量CTX组、VCR联合小剂量CTX、VCR联合大剂量三组,观察用药期间发生的不良事件,实时荧光定量RT-PCR检测BAFF mRNA表达水平。结果⑴VCR联合小剂量CTX组不良事件发生率与大剂量CTX组、VCR联合大剂量CTX组差异无统计学意义;⑵在基线时、12周时,VCR联合小剂量CTX组BAFF mRNA表达水平与大剂量CTX组、VCR联合大剂量CTX比较差异无统计学意义;⑶三组治疗前后BAFF mRNA表达水平明显下降,差异有统计学意义(P<0.05)。结论 VCR联合小剂量CTX治疗SLE疗效确切,副作用无明显增加。 Objective To investigate the safety and efficacy of vincristine (VCR) combined with low dose cyclophosphamide (CTX) in the treatment of systemic lupus erythematosus (SLE) and its effect on the expression of B cell activation factor (BAFF) mRNA. Methods A randomized, controlled study was conducted in 12 weeks. The included SLE patients were divided into high-dose CTX group, VCR combined with low-dose CTX and VCR combined with high-dose three groups to observe the adverse events during the treatment. Real-time fluorescent quantitative RT- mRNA expression level. Results (1) The incidence of adverse events in VCR combined with low-dose CTX group was not significantly different from high-dose CTX group and VCR combined with high-dose CTX group. (2) At 12 weeks, the expression of BAFF mRNA in VCR combined with low- The CTX group and VCR combined with high-dose CTX showed no significant difference (P> 0.05). (3) The expression of BAFF mRNA in the three groups before and after treatment were significantly decreased (P <0.05). Conclusion VCR combined with low-dose CTX treatment of SLE exact effect, no significant increase in side effects.