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目的观察高强度聚焦超声(high intensity focused ultrasound,HIFU)联合米非司酮治疗子宫腺肌病的疗效。方法 100例子宫腺肌病患者随机分为研究组(HIFU联合米非司酮治疗)和对照组(仅用HIFU治疗),比较两组患者治疗前后的临床症状、子宫体积及病灶大小等变化。结果治疗12月后所有患者中Ⅴ~Ⅵ级疼痛比例由治疗前的22%降至7%,子宫平均体积缩小18%,病灶体积缩小26%。两组比较,研究组患者在治疗6月后及12月的痛经缓解率优于对照组(P<0.05),研究组患者贫血缓解率高于对照组(P<0.05)。结论 HIFU联合米非司酮及仅用HIFU治疗子宫腺肌病均有效,HIFU联合米非司酮治疗子宫腺肌病的近期疗效优于单纯HIFU治疗。
Objective To observe the efficacy of high intensity focused ultrasound (HIFU) combined with mifepristone in the treatment of adenomyosis. Methods 100 patients with adenomyosis were randomly divided into study group (HIFU plus mifepristone treatment) and control group (HIFU treatment alone). The clinical symptoms, uterine volume and lesion size were compared between the two groups before and after treatment. Results All patients in grade Ⅴ to Ⅵ pain decreased from 22% before treatment to 7% after 12 months of treatment. The average uterine volume was reduced by 18% and the lesion volume was reduced by 26%. The rate of dysmenorrhea in study group was better than that in control group (P <0.05) after 6 months and 12 months of treatment. The rate of anemia in study group was higher than that in control group (P <0.05). Conclusion HIFU combined with mifepristone and only HIFU treatment of adenomyosis are effective, HIFU combined with mifepristone in the treatment of adenomyosis better than simple HIFU treatment.