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目的:探讨在低密度脂蛋白胆固醇(LDL-C)水平正常的急性冠脉综合征(ACS)患者联合测定心型脂肪酸结合蛋白(h-FABP),并超敏C-反应蛋白(hs-CRP)的临床意义。方法:测定28例经冠脉造影排除冠心病的住院患者(对照组)和84例经冠状动脉造影确诊为ACS且LDL-C正常的患者(ACS组)的h-FABP,比较两组间的阳性率。同时测定两组hs-CRP水平,比较其差异,ACS患者又被分为不稳定型心绞痛(UAP)、非ST段抬高型心肌梗塞(NSTEMI)、ST段抬高型心肌梗塞(STEMI)三组,比较各组间hs-CRP水平。结果:ACS患者h-FABP阳性率(72.6%)显著高于对照组的(7.1%)P<0.01。ACS患者的hs-CRP水平明显高于对照组[(27.42±12.70)mg/L∶(4.95±3.14)mg/L,P<0.05],且随着病变进一步进展,其水平亦升高,组间差异显著(P均<0.05)。结论:h-FABP联合hs-CRP可提高ACS早期诊断的准确性,同时hs-CRP水平能预测病变的进展程度。
Objective: To investigate the association of hs-CRP and hs-CRP in acute coronary syndrome (ACS) patients with normal LDL-C levels. ) Clinical significance. Methods: The h-FABP levels were measured in 28 hospitalized patients with coronary artery disease who underwent coronary angiography (control group) and 84 patients who underwent coronary angiography for diagnosis of ACS with normal LDL-C (ACS group) Positive rate. The levels of hs-CRP in the two groups were measured at the same time. The patients with ACS were divided into unstable angina pectoris (UAP), non-ST-segment elevation myocardial infarction (NSTEMI), ST-segment elevation myocardial infarction Group, hs-CRP levels were compared between groups. Results: The positive rate of h-FABP in ACS patients (72.6%) was significantly higher than that in controls (7.1%) (P <0.01). The level of hs-CRP in ACS patients was significantly higher than that in the control group [(27.42 ± 12.70) mg / L vs (4.95 ± 3.14) mg / L, P <0.05] There was significant difference between them (all P <0.05). Conclusion: h-FABP combined with hs-CRP can improve the accuracy of early diagnosis of ACS, hs-CRP level can predict the progression of the disease.