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美《科学文摘》1982年6月报道:人们或许有一天能通过一种简单的试验——呼吸分析,就可以发现他们是否对癌有易感性。据该试验发明者,芝加哥大学的科塔克(Alvin Kotake)说,此呼吸试验是测定一组细胞色素P_1-450酶的数量。他正在应用这种试验探求体内此种酶的水平与对癌易感性之间的关系。在体内合成作为一种防御机制的细胞色素P_1-450,已知能灭活某些有害的药物和化学物质。从而可以预料,这种酶存在越多,机体抗毒性的能力就越大。然而在对小鼠的研究中,其他研究人员发现这种防御作用适得其反:大量的
The United States, “Science Digest” reported in June 1982: People may one day be able to find out whether they are susceptible to cancer through a simple test - respiratory analysis. According to Alvin Kotake of the University of Chicago, the test inventor said the respiration test was to determine the number of cytochrome P 1 -450 enzymes. He is using this test to explore the relationship between the level of this enzyme in vivo and the susceptibility to cancer. The synthesis of cytochrome P 1 -450 as a defense mechanism in vivo is known to inactivate certain harmful drugs and chemicals. It can therefore be expected that the more this enzyme is present, the greater the organism’s ability to resist toxicity. However, in the study of mice, other researchers found that this defensive effect was counterproductive: a large amount of