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目的探讨腹腔液白细胞介素-10与子宫内膜异位症发病机制的相关性。方法收集近一年子宫内膜异位症和子宫肌瘤、卵巢良性肿瘤患者腹腔液,采用双抗体夹心酶联免疫吸附法(ELISA)测定IL-10浓度。结果子宫内膜异位症患者腹腔液中IL-10的浓度明显低于对照组腹腔液中浓度。两组间比较P<0.01,具有显著性差异。结论子宫内膜异位症腹腔液中IL-10的浓度降低,对T细胞和单核巨噬细胞激活抑制作用降低,可能与内异症免疫发病机制有关。
Objective To investigate the correlation between peritoneal fluid interleukin-10 and the pathogenesis of endometriosis. Methods The peritoneal fluid of patients with endometriosis, uterine fibroids and benign ovarian tumors was collected in the past year. IL-10 concentration was measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results The concentration of IL-10 in peritoneal fluid of patients with endometriosis was significantly lower than that in the control group. P <0.01 between the two groups, with significant differences. Conclusions The concentration of IL-10 in peritoneal fluid of patients with endometriosis is decreased and the inhibition of T-cell and monocyte-macrophage activation is decreased, which may be related to the pathogenesis of endometriosis.