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Connexin hemichannels have long been considered asmere structural precursors for gap junctions.In the last decade,it has become clear that they also act as individual channels,connecting the intracellular compartment and the extracellular environment.Impairement of connexin hemichannel functionality may result in disturbance of homeostasis,as exemplified in the current paper for the intestine and the liver.Research in this field still has a number of shortcomings,of which some are also discussed here.
Connexin hemichannels have long been considered asmere structural precursors for gap junctions. In the last decade, it has become clear that they also act as individual channels, connecting the intracellular compartment and the extracellular environment. Implantation of connexin hemichannel functionality may result in disturbance of homeostasis , as well in the current paper for the intestine and the liver. Research in this field still has a number of shortcomings, of which some of are also discussed here.