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[目的]探讨CD44v6蛋白在青年胃腺癌中的表达及其与临床病理特征之间的关系。[方法]收集49例青年胃腺癌患者临床病理资料,采用免疫组化SP法检测CD44v6蛋白的表达情况。[结果]CD44v6蛋白在青年胃腺癌组织中的阳性表达率为65.3%(32/49),其阳性表达与胃腺癌临床分期、淋巴结转移有关(P<0.05),与浆膜浸润接近相关(P=0.050),而与性别、分化程度和远处器官转移无关(P>0.05)。CD44v6蛋白阴性组3年生存率高于CD44v6蛋白阳性组(P=0.040)。[结论]检测青年胃腺癌患者组织中CD44v6蛋白表达有助于指导临床治疗和预后判断。
[Objective] To investigate the expression of CD44v6 protein in young patients with gastric adenocarcinoma and its relationship with clinicopathological features. [Methods] The clinicopathological data of 49 patients with gastric adenocarcinoma were collected. The expression of CD44v6 protein was detected by immunohistochemical SP method. [Results] The positive expression rate of CD44v6 protein in young patients with gastric adenocarcinoma was 65.3% (32/49). The positive expression of CD44v6 protein was correlated with clinical stage and lymph node metastasis (P <0.05), and was closely related to serosal invasion = 0.050), but not with sex, degree of differentiation and distant organs metastasis (P> 0.05). The 3-year survival rate of CD44v6 negative group was higher than that of CD44v6 positive group (P = 0.040). [Conclusion] Detecting the expression of CD44v6 in the tissues of young patients with gastric adenocarcinoma helps to guide clinical treatment and prognosis.