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本文报告在斯里兰卡使用氯喹治疗后发生再生障碍性贫血的3个病例,其中1例后来转变为急性粒细胞性白血病。2例曾长期采用大剂量氯喹治疗,还有1例只用小剂量治疗3周就出现全细胞减少及再生障碍性不良。例1是60岁男性盘状红斑性狼疮患者采用大剂量氯喹治疗,几个月后出现贫血及网织红细胞减少而停药,18个月后因罹患脑型疟疾再用氯喹治疗,27个月后因右侧手臂肿胀及发热1月入院。患者面色苍白,全身性淋巴腺肿大,但肝脾未及。骨髓检查主要为未分化的、过氧化酶阴性的原始细胞,其中有些呈幼稚粒单核样(Myelomonocytoid)表现。骨髓中巨核细胞很少。
This article reports three cases of aplastic anemia following chloroquine treatment in Sri Lanka, of which one case later became acute myeloid leukemia. 2 cases had long-term use of high-dose chloroquine therapy, there are 1 cases of only a small dose of treatment for 3 weeks there pancytopenia and aplastic dysplasia. Case 1 was a 60-year-old man with discoid lupus erythematosus who was treated with high-dose chloroquine, with anemia and reticulocyte a few months later discontinued, eighteen months later with cerebral malaria treated with chloroquine, and 27 months After the right arm swelling and fever January admission. Patient pale, systemic lymphadenopathy, but liver and spleen not yet. Bone marrow examination is mainly undifferentiated, peroxidase-negative primitive cells, some of which showed a juvenile mononuclear species (Myelomonocytoid) performance. There are few megakaryocytes in the bone marrow.