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HBV表面的多肽链具有多聚人血清白蛋白受体(pHSA-r)功能。当HBsAg合成并被装配成完整的HBV颗粒时,所表达的pHSA-r量远较低水平HBV复制时为多。为了估价δ感染对pHSA-r表达的影响及抗-δ和抗白蛋白抗体(AAA)在形成HBs-Ag/IgM复合物中的作用,作者对一组HBV感染患者进行了研究。血清采自86例急慢性HBsAg阳性肝病患者。其中30例抗-HBc IgM阳性,临床表现和生化改变符合急性肝炎;56例为慢性HBV感染(9例无症状携带者、29例慢性肝炎、18例非活动性肝硬变)。除5例肝硬变腹水患者及携带者外,其他患者均作了肝活检。
The polypeptide chain on the surface of HBV has the function of poly-serum albumin receptor (pHSA-r). When HBsAg is synthesized and assembled into intact HBV particles, the amount of pHSA-r expressed is far more than that at low levels of HBV replication. To assess the effect of δ-infection on the expression of pHSA-r and the role of anti-δ and anti-albumin antibodies (AAA) in the formation of HBs-Ag / IgM complexes, a group of HBV-infected patients was studied. Serum collected from 86 patients with acute and chronic HBsAg-positive liver disease. Among them, 30 cases were positive for anti-HBc IgM, the clinical manifestations and biochemical changes were in accordance with acute hepatitis, 56 cases were chronic HBV infection (9 asymptomatic carriers, 29 chronic hepatitis and 18 inactive cirrhosis). In addition to 5 patients with liver cirrhosis ascites and carriers, other patients were biopsied.