毛细血管渗漏综合征(capillary leak syndrome,CLS)是由于某种因素导致广泛的毛细血管内皮损伤、血管通透性增加、大量血浆蛋白渗漏到组织间隙引起的一组综合征,临床表现往往复杂多样~([1]),特征为难以解释的毛细血管高渗状态。其实质是血管内皮细胞炎性损伤,肺泡水肿、气体交换受限,组织缺氧,从而加重毛细血管损伤,最终可导致器官功能障碍,甚至多器官功能障碍综合征(MODS)~([2-3])。近 Capillary leak syndrome (CLS) is a group of syndromes caused by some factors leading to extensive capillary endothelial injury, increased vascular permeability and massive plasma protein leakage into the interstitial space. The clinical manifestations are often Complex and diverse ~ ([1]), characterized by difficult to explain the capillary hypertonic state. Its essence is vascular endothelial cell inflammatory injury, alveolar edema, gas exchange is limited, hypoxia, thereby aggravating capillary damage, which can eventually lead to organ dysfunction, and even multiple organ dysfunction syndrome (MODS) ~ ([2- 3]). near