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目的 探讨P 糖蛋白 (P glycoprotein ,P gp)和谷胱甘肽S转移酶π(glutathionetransferase π ,GST π)表达与化疗药物耐受性的关系。方法 采用免疫组化过氧化物酶标记法检测口腔颌面部鳞癌和正常口腔粘膜组织样本中P gp和GST π的表达 ,结合MTT药敏检测结果分析。结果 P gp和GST π在恶性肿瘤中阳性表达率分别为 5 7 1%和 5 3 6 % ,在正常组织中未见表达 ;P gp的表达与化疗药物总体耐受性有关 ;GST π的表达与患者对顺铂耐受性有关。结论 P gp和GST π的阳性表达提示患者有化疗药物耐受倾向。P gp和GST π检测对判断口腔颌面部恶性肿瘤化疗耐药性有指导意义。
Objective To investigate the relationship between the expressions of P-glycoprotein (P-gp) and glutathionetransferase π (GST π) and chemotherapeutic drug resistance. Methods The expressions of P gp and GST π in oral and maxillofacial squamous cell carcinoma and normal oral mucosa tissues were detected by immunohistochemical method of peroxidase and combined with MTT assay. Results The positive rates of P gp and GST π in malignant tumors were 57.1% and 53.6%, respectively, which were not found in normal tissues. The expression of P gp was related to the overall tolerance of chemotherapy drugs. The expression of GST π And patients with cisplatin resistance. Conclusion The positive expression of P gp and GST π indicates that patients have the tendency of chemotherapy drug tolerance. P gp and GST π detection of oral and maxillofacial malignancy to determine the resistance of chemotherapy has guiding significance.