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近年来,以刺激响应水凝胶为载体的智能药物释放体系尤为引人注意,因其药剂可响应病理环境信号自反馈而控制释放.采用天然高分子化合物如壳聚糖组成的脉冲药物释放体系颇为有利.因壳聚糖(1,4-α-乙酸胺基-α-脱氧-β-D葡聚糖)为自然界最丰富的多糖之一,可由虾壳和蟹壳中的甲壳素脱乙酰化制备,且无毒能为生物体吸收,在体内有降低脂质的作用.Nishimura等将阿霉素负载于壳聚糖微球,考察其抗肿瘤特性.Chandy等则用于壳
In recent years, the stimulus-responsive hydrogel-based smart drug delivery system is particularly attractive because of its ability to control release from the feedback of pathological signals via self-feedback, using a pulsed drug delivery system composed of natural polymeric compounds such as chitosan Due to the fact that chitosan (1,4-α-amido-α-deoxy-β-D glucan) is one of the most abundant polysaccharides in nature and can be produced from chitin in shrimp shell and crab shell Acetylation, and non-toxic for the body to absorb, reduce the role of lipid in the body.Nishimura et al doxorubicin loaded on chitosan microspheres, to investigate its anti-tumor properties.Chandy, etc. for shell