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目的探讨急性脑梗死患者血清超敏C-反应蛋白(hs-CRP)测定的临床价值。方法选择脑梗死患者100例(脑梗死组)及健康体检者80例(对照组),根据患者入院时的神经功能缺损评分将脑梗死组又分为轻型亚组48例,中型亚组24例,重型亚组28例。分别对脑梗死患者治疗前及治疗2周后血清hs-CRP含量测定比较;并分析比较急性脑梗死患者临床病情分型与血清hs-CRP水平的关系。结果急性脑梗死患者治疗前hs-CRP含量明显高于正常对照组(P<0.01),治疗2周后与正常对照组比较差异无统计学意义(P>0.05);脑梗死各组间血清hs-CRP含量两两比较差异均有统计学意义(P<0.01),脑梗死患者hs-CRP含量与其临床神经功能缺损程度评分呈正相关。结论血清hs-CRP不仅参与了脑缺血后的炎性反应,而且与病变严重程度有关,血清hs-CRP水平测定对判断病情及评价疗效有重要的临床价值。
Objective To investigate the clinical value of serum hs-CRP in patients with acute cerebral infarction. Methods 100 patients with cerebral infarction (cerebral infarction group) and 80 healthy subjects (control group) were divided into mild subgroup (48 cases) and middle subgroup (24 cases) according to neurological deficit score , Heavy subgroup of 28 cases. The levels of serum hs-CRP in patients with cerebral infarction before treatment and after 2 weeks of treatment were compared. The relationship between the clinical pathological type and serum hs-CRP level was analyzed. Results The levels of hs-CRP in patients with acute cerebral infarction before treatment were significantly higher than those in normal control group (P <0.01). There was no significant difference between the two groups after 2 weeks of treatment (P> 0.05) There was a significant difference of -CRP between two groups (P <0.01). There was a positive correlation between hs-CRP and clinical neurological deficit scores in patients with cerebral infarction. Conclusion Serum hs-CRP is not only involved in the inflammatory reaction after cerebral ischemia, but also with the severity of the disease. The serum hs-CRP level has important clinical value in judging the disease and evaluating the curative effect.