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目的探讨三维适形放疗(3DCRT)与全颅放疗加三维适形放疗(WBRT+3DCRT)的疗效差别。方法 30例脑转移癌患者随机分为A、B两组。A组为三维适形放疗(3DCRT)DT组(14例):40-60Gy/(10-20次.3-4周);B组为全颅放疗加三维适形放疗(WBRT+3DCRT)组(16例):全脑放疗后给予局部病灶三维适形放疗,推量照射至DT:40～60Gy。结果三维适形放疗组放疗后局控率为78.5%,中位生存期11.5个月,全脑放疗加三维适形放疗组放疗后局控率为75.0%,中位生存期10个月,两组差别无统计学意义(P>0.05)。结论三维适形放疗和全颅放疗加三维适形放疗治疗单发脑转移瘤无明显差别。
Objective To investigate the difference between three-dimensional conformal radiotherapy (3DCRT) and total cranial radiotherapy plus three-dimensional conformal radiotherapy (WBRT + 3DCRT). Methods Thirty patients with brain metastases were randomly divided into A and B groups. Group A was 3DCRT DT group (14 cases): 40-60 Gy / (10-20 times. 3-4 weeks); Group B was total brain radiotherapy plus three-dimensional conformal radiation therapy (WBRT + 3DCRT) (16 cases): Three-dimensional conformal radiotherapy of local lesion was given after whole-brain radiotherapy, and the amount of irradiation was irradiated to DT: 40-60 Gy. Results The control rate of radiotherapy in three-dimensional conformal radiotherapy group was 78.5%, and the median survival time was 11.5 months. The global control rate of radiotherapy in whole-brain radiotherapy plus three-dimensional conformal radiotherapy group was 75.0% and the median survival time was 10 months. The difference was not statistically significant (P> 0.05). Conclusion Three-dimensional conformal radiotherapy and cranial radiotherapy combined with three-dimensional conformal radiotherapy single brain metastases no significant difference.