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病毒宁滴剂为广州中医药大学热带医学研究所和北京市宇维生科贸技术有限公司为寻求治疗感冒的有效手段而联合研制的 ,主要用于外感风热初起型感冒的中药滴鼻制剂 ,该药主要由清热解毒的柴胡、鱼腥草等中药提炼研制而成。为进一步探讨该药的药理机制 ,对其在体内体外的抑菌、抗炎作用进行了研究。结果发现病毒宁滴剂体外试验对 6种细菌菌株有不同程度的抑制作用 ,但作用不强 ;体内抗菌试验表明 ,病毒宁滴剂 2 5 0 0mg kg剂量组可降低金黄色葡萄球菌攻击小鼠的死亡率 (P <0 .0 0 5 ) ;病毒宁滴剂5 0 0mg kg剂量组具有抑制二甲苯致小鼠毛细血管通透性增加的作用 (P <0 .0 0 5 ) ;其 2 5mg kg、 5 0mg kg、10 0mg kg剂量组还具有抑制大鼠足跖肿胀形成的作用。表明病毒宁有一定的抑菌作用 ,尤其对金黄色葡萄球菌有较强体内保护作用 ,并有较明显的抗炎消除肿胀作用
The viral dripping drops were jointly developed by the Institute of Tropical Medicine of Guangzhou University of Chinese Medicine and Beijing Yuweisheng Science and Technology Co., Ltd. for the treatment of common cold. They are mainly used for the treatment of colds and colds. Preparations, the drug is mainly developed from detoxification of Bupleurum, Houttuynia and other traditional Chinese medicine. In order to further explore the pharmacological mechanism of the drug, its antibacterial and anti-inflammatory effects in vitro and in vivo were studied. The results showed that viral dripping in vitro test had different degrees of inhibition on six bacterial strains, but the effect was not strong; in vivo antibacterial test showed that viral dripping agent 250 mg kg dose group can reduce Staphylococcus aureus attack mice The mortality rate (P < 0.05) was significantly higher than that of the control group (P <0.05). The 500 mg dose of Ning Ding Drops had the effect of inhibiting the increase of capillary permeability induced by xylene (P <0.05); The 5 mg kg, 50 mg kg, and 100 mg kg dose groups also had the effect of inhibiting the formation of paw edema in rats. Shows that the virus has a certain degree of antibacterial activity, especially for Staphylococcus aureus has a stronger protective effect in vivo, and there are more obvious anti-inflammatory eliminate swelling